2016 - Recent
Constantin S, Pizano K, Matson K, Shan Y, Reynolds D, Wray S. (2021) An Inhibitory Circuit from Brainstem to GnRH neurons in Male Mice: A new Role for the RFRP Receptor. Endocrinology, bqab030.
Shan Y, Farmer S, Wray S. (2021) Drebrin Regulates Cytoskeleton Dynamics in Migrating Neurons through Interaction with CXCR4. PNAS 118(3):e2009493118.
Constantin S, Reynolds D, Oh A, Pizano K, Wray S. (2021) Nitric oxide resets kisspeptin-excited GnRH neurons via PIP2 replenishment. PNAS Jan 5;118(1):e2012339118.
Saglam A, Calof AL, Wray S. (2021) Novel factor in olfactory ensheathing cell-astrocyte crosstalk: Anti-inflammatory protein a-crystallin B. Glia. Apr;69(4):1022-1036.
Shan Y, Saadi H, Wray S. (2020) Heterogeneous Origin of Gonadotropin Releasing Hormone-1 Neurons in Mouse Embryos Detected by Islet-1/2 Expression. Frontiers in cell and development, 8:35.
Cho H-J, Shan Y, Whittington N, Wray S. (2019) Nasal placode development, GnRH neuronal migration and Kallmann Syndrome, Frontier in Cell and Developmental Biology
Saadi H*, Shan Y*, Marazziti D, Wray S. (2019) GPR37 Signaling Modulates Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Cells in Mice. Frontiers in cellular neuroscience, 13, 200.
Dairaghi L, Flannery E, Giacobini P, Saglam A, Saadi H, Constantin S, Casoni F, Howell BW, Wray S. (2018) Reelin Can Modulate Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Neurons via the Canonical Pathway. Front Cell Neurosci 12:228.
Constantin S, Wray S. (2018) Nociceptin/Orphanin-FQ Inhibits Gonadotropin-Releasing Hormone Neurons via G-Protein Gated Inwardly Rectifying Potassium Channels. eNeuro 5(6).
Constantin S, Klenke U, Wray S. (2016) BPA directly decreases GnRH neuronal activity via noncanonical pathway. Endocrinology 157:1980-90.
Constantin S, Wray S. (2016) Galanin Activates G Protein Gated Inwardly Rectifying Potassium Channels and Suppresses Kisspeptin-10 Activation of GnRH Neurons. Endocrinology 157:3197-212.
Shan Y, Wray S. (2018), Part II-2: Prenatal Development of GnRH Neurons, In book: The GnRH Neurons and its Control, Editors: Allan Herbison and Tony Plant, Wiley, pg. 15-43.
Proper assembly of neural circuits requires newly born neurons to migrate from their place of origin to their final location and establish appropriate functional activity. The Cellular and Developmental Neurobiology Section conducts research on 1) Cell lineage, Neuronal Migration and Axonal Targeting and 2) Mechanisms underlying Neuronal Activity. Our focus is on development and regulation of GnRH neurons, cells essential for reproduction. GnRH neurons originate in nasal regions and migrate on olfactory axons into the brain. In reproductively mature animals, these neurons release peptide in a pulsatile fashion. Disruption of the development or regulation of this system results in reproductive dysfunction. Developmental projects include craniofacial development, differentiation and migration of GnRH cells, and olfactory axon outgrowth. Neuronal activity projects utilize the GnRH system to study molecular and cellular properties of neuronal activity (individual cells and neuronal population dynamics) at different developmental, metabolic and/or reproductive states, and the link between neuronal activity and secretion.
Student NameAybike SaglamCurrent PositionPostdoc Affiliate, Wray Lab, NIH