Computation and circuitry in the mammalian retina
The mammalian retina is composed of ~100 distinct neuronal cell types. Understanding how these cell types work in concert to process and encode visual scenes is a major goal of my laboratory. I will describe the use of a large-scale multi-electrode array to record the spiking activity from hundreds of retinal ganglion cells simultaneously, the output neurons of the retina. This technique allows us to measure how visual scenes are signaled by a large diversity (>10) of retinal ganglion cell types. We are combining these measurements with chemogenetic approaches to manipulate the activity of genetically defined retinal interneurons to deduce their connectivity and function within the circuit.
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